A fully asymptotic preserving decomposed multi-group method for the frequency-dependent radiative transfer equations

The opacity of FRTE depends on not only the material temperature but also the frequency, whose values may vary several orders of magnitude for different frequencies. The gray radiation diffusion and frequency-dependent diffusion equations are two simplified models that can approximate the solution to FRTE in the thick opacity regime. The frequency discretization for the two limit models highly affects the numerical accuracy. However, classical frequency discretization for FRTE considers only the absorbing coefficient. In this paper, we propose a new decomposed multi-group method for frequency discretization that is not only AP in both gray radiation diffusion and frequency-dependent diffusion limits, but also the frequency discretization of the limiting models can be tuned. Based on the decomposed multi-group method, a full AP scheme in frequency, time, and space is proposed. Several numerical examples are used to verify the performance of the proposed scheme.Comment: 36 pages, 14 figure

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr Virus infection. Here we resolve the major genetic influences for NPC incidence using a genome-wide association study (GWAS), independent cohort replication, and high-resolution molecular HLA class I gene typing including 4,055 study participants from the Guangxi Zhuang Autonomous Region and Guangdong province of southern China. We detect and replicate strong association signals involving SNPs, HLA alleles, and amino acid (aa) variants across the major histocompatibility complex-HLA-A, HLA –B, and HLA -C class I genes (PHLA-A-aa-site-62 = 7.4×10−29; P HLA-B-aa-site-116 = 6.5×10−19; P HLA-C-aa-site-156 = 6.8×10−8 respectively). Over 250 NPC-HLA associated variants within HLA were analyzed in concert to resolve separate and largely independent HLA-A, -B, and -C gene influences. Multivariate logistical regression analysis collapsed significant associations in adjacent genes spanning 500 kb (OR2H1, GABBR1, HLA-F, and HCG9) as proxies for peptide binding motifs carried by HLA- A*11:01. A similar analysis resolved an independent association signal driven by HLA-B*13:01, B*38:02, and B*55:02 alleles together. NPC resistance alleles carrying the strongly associated amino acid variants implicate specific class I peptide recognition motifs in HLA-A and -B peptide binding groove as conferring strong genetic influence on the development of NPC in China

Suppressing the zero-frequency component of hologram with Hilbert-Huang transform in single-shot off-axis holography

This paper proposes a method based on Hilbert-Huang transform to suppress the zero-frequency component of holograms with only one shot. It can effectively improve the quality of reconstructed phase objects

Capturing the Motion of Laser Pulse in Photoresist Mixture with Compressed Ultrafast Photography

Imaging the interaction between the laser pulse and photoresist mixture on the ultrafast time scale can track the path of the light pulse and reveal the procedure of the microstructure machining. However, most existing imaging technologies suffer from problems such as requiring multiple repeated shots or a limited time resolution. To overcome these problems, we propose to capture the motion of laser pulses in a photoresist mixture by using compressed ultrafast photography (CUP). In this method, we can recover the motion process of non-repeatable events with a single shot at the time-resolution of about 1.54×1011 fps, where the depth of the imaging sequence reaches hundreds of frames. To verify the effectiveness of the proposed method, we estimate the speed of the laser pulse in a photoresist mixture and evaluate the similarity between the image captured by a streak camera and our reconstructed ultrafast sequence; the results validate the reliability of our proposed method

Speckle Noise Suppression Based on Empirical Mode Decomposition and Improved Anisotropic Diffusion Equation

Existing methods to eliminate the laser speckle noise in quantitative phase imaging always suffer from the loss of detailed phase information and the resolution reduction in the reproduced image. To overcome these problems, this paper proposes a speckle noise suppression method based on empirical mode decomposition. Our proposed method requires only one image without additional equipment and avoids the complicated process of searching the optimal processing parameters. In this method, we use empirical mode decomposition to highlight the high frequency information of the interference image and use the Canny operator to perform edge detection, so the diffusion denoising process is guided by high-precision detection results to achieve better results. To validate the performance of our proposed method, the phase maps processed by our proposed method are compared with the phase maps processed by the improved anisotropic diffusion equation method with edge detection, the mean filter method and the median filter method. The experimental results show that the method proposed in this paper not only has a better denoising effect but also preserves more details and achieves higher phase reconstruction accuracy

Capturing the Motion of Laser Pulse in Photoresist Mixture with Compressed Ultrafast Photography

Imaging the interaction between the laser pulse and photoresist mixture on the ultrafast time scale can track the path of the light pulse and reveal the procedure of the microstructure machining. However, most existing imaging technologies suffer from problems such as requiring multiple repeated shots or a limited time resolution. To overcome these problems, we propose to capture the motion of laser pulses in a photoresist mixture by using compressed ultrafast photography (CUP). In this method, we can recover the motion process of non-repeatable events with a single shot at the time-resolution of about (Formula presented.) fps, where the depth of the imaging sequence reaches hundreds of frames. To verify the effectiveness of the proposed method, we estimate the speed of the laser pulse in a photoresist mixture and evaluate the similarity between the image captured by a streak camera and our reconstructed ultrafast sequence; the results validate the reliability of our proposed method

Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein

Human papillomavirus (HPV) E6 oncoprotein targets certain tumor suppressors such as MAGI-1 and SAP97/hDlg for degradation. A short peptide at the C terminus of E6 interacts specifically with the PDZ domains of these tumor suppressors, which is a property unique to high-risk HPVs that are associated with cervical cancer. The detailed recognition mechanisms between HPV E6 and PDZ proteins are unclear. To understand the specific binding of cellular PDZ substrates by HPV E6, we have solved the crystal structures of the complexes containing a peptide from HPV18 E6 bound to three PDZ domains from MAGI-1 and SAP97/Dlg. The complex crystal structures reveal novel features of PDZ peptide recognition that explain why high-risk HPV E6 can specifically target these cellular tumor suppressors for destruction. Moreover, a new peptide-binding loop on these PDZs is identified as interacting with the E6 peptide. Furthermore, we have identified an arginine residue, unique to high-risk HPV E6 but outside the canonical core PDZ recognition motif, that plays an important role in the binding of the PDZs of both MAGI-I and SAP97/Dlg, the mutation of which abolishes E6's ability to degrade the two proteins. Finally, we have identified a dimer form of MAGI-1 PDZ domain 1 in the cocrystal structure with E6 peptide, which may have functional relevance for MAGI-1 activity. In addition to its novel insights into the biochemistry of PDZ interactions, this study is important for understanding HPV-induced oncogenesis; this could provide a basis for developing antiviral and anticancer compounds